Insulin-like growth factors and insulin: comparative aspects
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چکیده
منابع مشابه
Insulin, insulin-like growth factors and neoplasia.
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• The insulin-like growth factor (IGF) family of peptides, binding proteins, and receptors are important for normal human growth and development and are involved in the specialized functions of most physiologic systems. Most members of the IGF system are expressed by different cancer cells and may play an important role in the propagation of these malignancies. New therapies aimed at modulating...
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The last decade has been characterized by a major investigative thrust into the physiology of two unique but ubiquitous peptides, insulin-like growth factor (IGF)-I and IGF-II. The regulatory systems that control the tissue bioactivity of the IGFs have been delineated, and subcellular signaling mechanisms have been clarified. Clearly, both tissue and circulating growth factor concentrations are...
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© 1999 Journals of Reproduction and Fertility 1359-6004/99 $15.00 The insulin-like growth factors, IGF-I and IGF-II, have effects on metabolism, growth, proliferation and differentiation in many tissues and cell types (Jones and Clemmons, 1995) and are therefore important modulators of many aspects of physiology. Insulin-like growth factor actions are largely mediated via the type 1 IGF recepto...
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ژورنال
عنوان ژورنال: Diabetologia
سال: 1985
ISSN: 0012-186X,1432-0428
DOI: 10.1007/bf00281982